Every cell is coated in a complex matrix of carbohydrates, called the glycocalyx, that facilitates its interactions with the environment. Neurons are no exception. The neuronal glycocalyx is highly enriched in negatively-charged sialic acid residues, and defects in glycosylation are associated with neurological deficits including seizures and psychomotor retardation. However, the functional role of these glycans in establishing and maintaining neuronal behavior is poorly understood. My research seeks to uncover how changes in sialylation state affect neuronal behavior in healthy and inflammatory conditions.